Role of Glutamine Metabolism in Host Defense Against Mycobacterium tuberculosis Infection

doi:10.1093/infdis/jiy709

Article

Role of Glutamine Metabolism in Host Defense Against Mycobacterium tuberculosis Infection

7 Dec 2018

Abstract excerpt

BACKGROUND: Rewiring cellular metabolism is important for activation of immune cells during host defense against Mycobacterium tuberculosis. Glutamine has been implicated as an immunomodulatory nutrient, but its role in the response to M. tuberculosis is unknown. METHODS: We assessed expression of glutamine pathway genes in M. tuberculosis-infected macrophages and blood transcriptomic profiles of individuals with...

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