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Article

SAMHD1 prevents autoimmunity by maintaining genome stability

21 Jan 2014

Abstract excerpt

OBJECTIVES: The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs). Mutations in SAMHD1 cause Aicardi-Goutières syndrome (AGS), an inflammatory disorder that shares phenotypic similarity with systemic lupus erythematosus, including activation of antiviral type 1 interferon (IFN). To further define the...

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PMID: 24445253
DOI: 10.1136/annrheumdis-2013-204845

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