Article

PharmOmics: A Species- and Tissue-specific Drug Signature Database and Online Tool for Drug Repurposing

2019-11-11

Abstract excerpt

Drug development has been hampered by a high failure rate in clinical trials due to efficacy or safety issues not predicted by preclinical studies in model systems. A key contributor is our incomplete understanding of drug functions across organ systems and species. Therefore, elucidating species- and tissue-specific actions of drugs can provide systems level insights into therapeutic efficacy, potential adverse e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5114a71e-fbd9-5c23-bc00-643f0de5199e
DOI: 10.1101/837773

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PharmOmics: A Species- and Tissue-specific Drug Signature Database and Online Tool for Drug RepurposingDOI 10.1101/837773Read

Transcriptomic profiling of hepatic tissues for drug metabolism genes in nonalcoholic fatty liver disease: A study of human and animalsSemantic proximity Read

Research on the Species Difference of the Hepatotoxicity of Medicine Based on TranscriptomeSemantic proximity Read

The Drug Repurposing Encyclopedia (DRE): a web server for systematic drug repurposing across 20 organismsSemantic proximity Read

DrugBank 5.0: a major update to the DrugBank database for 2018.Semantic proximity Read

Safetyome and specialized panels for over 3,000 phenotypes: a systematic and translational approach using human genetics and pharmacology.Semantic proximity Read

Linking PharmGKB to phenotype studies and animal models of disease for drug repurposing.Semantic proximity Read

Integrative Omics for Informed Drug Repurposing: Targeting CNS DisordersSemantic proximity Read

Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity.Semantic proximity Read

ProToxNet: Expression-Aware Proteome-Wide Binding for Tissue-Stratified Adverse Event PredictionSemantic proximity Read

Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety LiabilitiesSemantic proximity Read

Prioritization of Potential Drugs Through Pathway-Based Drug Repurposing and Network Proximity AnalysisSemantic proximity Read

Unveiling the mechanisms of nephrotoxicity caused by nephrotoxic compounds using toxicological network analysisSemantic proximity Read