Article

ProToxNet: Expression-Aware Proteome-Wide Binding for Tissue-Stratified Adverse Event Prediction

2026-07-03

Abstract excerpt

<title>Abstract</title> <p>Predicting which drugs cause which adverse events---and in which tissues---remains a core unsolved challenge in computational drug safety. Here we present ProToxNet, a framework integrating proteome-wide predicted drug--protein binding with tissue-specific gene expression to generate 68-dimensional tissue exposure profiles for 4,310 drugs across 68 human tissues. A diagonal bilinear int...

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Literature Corpus work: 7a32ec1e-4f05-512a-af4c-1b40faefa41c
DOI: 10.21203/rs.3.rs-10147144/v1

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