HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients.

doi:10.3389/fimmu.2021.661135

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Article

HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients.

Frontiers in immunology - 1 Jan 2021

Satapornpong Patompong, Pratoomwun Jirawat, Rerknimitr Pawinee, Klaewsongkram Jettanong, Nakkam Nontaya, Rungrotmongkol Thanyada, Konyoung Parinya, Saksit Niwat, Mahakkanukrauh Ajanee, Amornpinyo Warayuwadee, Khunarkornsiri Usanee, Tempark Therdpong, Wantavornprasert Kittipong, Jinda Pimonpan, Koomdee Napatrupron, Jantararoungtong Thawinee, Rerkpattanapipat Ticha, Wang Chuang-Wei, Naisbitt Dean, Tassaneeyakul Wichittra, Ariyachaipanich Manasalak, Roonghiranwat Thapana, Pirmohamed Munir, Chung Wen-Hung, Sukasem Chonlaphat

Abstract excerpt

HLA-B*13:01 allele has been identified as the genetic determinant of dapsone hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several studies. Dapsone hydroxylamine (DDS-NHOH), an active metabolite of dapsone, has been believed to be responsible for DHS. However, studies have not highlighted the importance of other genetic polymorphisms in dapsone-induced severe cutaneous adverse...

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PMID: 34017337
DOI: 10.3389/fimmu.2021.661135
PMCID: PMC8130671

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