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Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies in vitro , in animals, and in humans

20 Jan 1998

Abstract excerpt

A method for measuring DNA synthesis and, thus, cell proliferation, in vivo is presented. The technique consists of administering [6,6-2H2]Glc or [U-13C]Glc, isolating genomic DNA, hydrolyzing enzymatically to free deoxyribonucleosides, and derivatizing for GC-MS analysis of dA or dG isotopic enrichments, or both. Comparison of dA or dG to extracellular Glc enrichment (with a correction for intracellular...

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PMID: 9435257
DOI: 10.1073/pnas.95.2.708

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