Article
In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow.
Cancer research - 15 Dec 2008
van Gent Rogier, Kater Arnon P, Otto Sigrid A, Jaspers A, Borghans José A M, Vrisekoop Nienke, Ackermans Mariëtte A T, Ruiter An F C, Wittebol Shulamiet, Eldering Eric, van Oers Marinus H J, Tesselaar Kiki, Kersten Marie José, Miedema Frank
Abstract excerpt
Although accumulating evidence indicates that chronic lymphocytic leukemia (CLL) is a disease with appreciable cell dynamics, it remains uncertain whether this also applies to patients with stable disease. In this study, (2)H(2)O was administered to a clinically homogeneous cohort of nine stable, untreated CLL patients. CLL dynamics in blood and bone marrow were determined and compared with normal B-cell dynamics...
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