Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by<i>in Vivo</i>Thymidine Analog Incorporation and Radiocarbon Dating

Abstract excerpt

AIMS: Diabetes mellitus results from an absolute or relative deficiency of insulin-producing pancreatic β-cells. The turnover rate of adult human β-cells remains unknown. We employed two techniques to examine adult human islet β-cell turnover and longevity in vivo. METHODS: Subjects enrolled in National Institutes of Health clinical trials received thymidine analogs [iododeoxyuridine (IdU) or bromodeoxyuridine...

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