Article
Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia.
Leukemia - 1 Jun 2017
Murphy E J, Neuberg D S, Rassenti L Z, Hayes G, Redd R, Emson C, Li K, Brown J R, Wierda W G, Turner S, Greaves A W, Zent C S, Byrd J C, McConnel C, Barrientos J, Kay N, Hellerstein M K, Chiorazzi N, Kipps T J, Rai K R
Abstract excerpt
The clinical course of patients with recently diagnosed early stage chronic lymphocytic leukemia (CLL) is highly variable. We examined the relationship between CLL-cell birth rate and treatment-free survival (TFS) in 97 patients with recently diagnosed, Rai stage 0-II CLL in a blinded, prospective study, using in vivo 2H2O labeling. Birth rates ranged from 0.07 to 1.31% new cells per day. With median follow-up of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.