Identification and characterization of human CD34 ⁺ and CD34 ^dim/- neutrophil-committed progenitors

Abstract excerpt

<h4>ABSTRACT</h4> We report the identification of human CD66b − CD64 dim CD115 − neutrophil-committed progenitors within SSC low CD45 dim CD34 + and CD34 dim/− bone marrow cells, that we named neutrophil myeloblast (NMs). CD34 + and CD34 dim/− NMs resulted as either CD45RA + or CD45RA − , with CD34 + CD45RA − NMs found as selectively expanded in chronic-phase chronic myeloid leukemia patients. By scR...

Topics

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• Acute Myeloid Leukemia Research
• Antigens, CD34
• Hematopoietic Stem Cell Transplantation
• Immune cells in cancer
• Leukemia, Myeloid, Acute
• Leukemia, Myelomonocytic, Chronic
• Mice, Inbred NOD
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

50cd31e7-465e-5a5b-82c1-0c9a2e9bebf1

DOI

10.1101/2021.04.30.442138