Article
Phenotypic characterization of leukemia-initiating stem cells in chronic myelomonocytic leukemia.
Leukemia - 1 Nov 2021
Eisenwort Gregor, Sadovnik Irina, Keller Alexandra, Ivanov Daniel, Peter Barbara, Berger Daniela, Stefanzl Gabriele, Bauer Karin, Slavnitsch Katharina, Greiner Georg, Gleixner Karoline V, Sperr Wolfgang R, Willmann Michael, Sill Heinz, Bettelheim Peter, Geissler Klaus, Deininger Michael, Rülicke Thomas, Valent Peter
Abstract excerpt
Chronic myelomonocytic leukemia (CMML) is a stem cell-derived neoplasm characterized by dysplasia, uncontrolled expansion of monocytes, and substantial risk to transform to secondary acute myeloid leukemia (sAML). So far, little is known about CMML-initiating cells. We found that leukemic stem cells (LSC) in CMML reside in a CD34+/CD38- fraction of the malignant clone. Whereas CD34+/CD38- cells engrafted NSGS...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.