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Sex specific emergence of trisomic <i>Dyrk1a</i> -related skeletal phenotypes in the development of a Down syndrome mouse model

2024-05-26

Abstract excerpt

Skeletal insufficiency affects all individuals with Down syndrome (DS) or Trisomy 21 (Ts21) and may alter bone strength throughout development due to a reduced period of bone formation and early attainment of peak bone mass compared to typically developing individuals. Appendicular skeletal deficits also appear in males before females with DS. In femurs of male Ts65Dn DS model mice, cortical deficits were pronounc...

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Literature Corpus work
509e679a-b00a-5bc8-beb3-8a7fc21eb2b2
DOI
10.1101/2024.05.24.595804
Open publication

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Sex specific emergence of trisomic <i>Dyrk1a</i> -related skeletal phenotypes in the development of a Down syndrome mouse modelDOI 10.1101/2024.05.24.595804
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