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Article

Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

20 Nov 2023

Abstract excerpt

Aberrant neurodevelopment in Down syndrome (DS)-caused by triplication of human chromosome 21-is commonly attributed to gene dosage imbalance, linking overexpression of trisomic genes with disrupted developmental processes, with DYRK1A particularly implicated. We hypothesized that regional brain DYRK1A protein overexpression in trisomic mice varies over development in sex-specific patterns that may be distinct...

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PMID: 37992782
DOI: 10.1016/j.nbd.2023.106359

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