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Article

Sex-specific trisomic Dyrk1a-related skeletal phenotypes during development in a Down syndrome model.

Disease models & mechanisms - 1 Sept 2024

LaCombe Jonathan M, Sloan Kourtney, Thomas Jared R, Blackwell Matthew P, Crawford Isabella, Bishop Flannery, Wallace Joseph M, Roper Randall J

Abstract excerpt

Skeletal insufficiency affects all individuals with Down syndrome (DS) or trisomy 21 and may alter bone strength throughout development due to a reduced period of bone formation and early attainment of peak bone mass compared to those in typically developing individuals. Appendicular skeletal deficits also appear in males before females with DS. In femurs of male Ts65Dn DS model mice, cortical deficits were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39136051
DOI: 10.1242/dmm.050914
PMCID: PMC11449447

Genes

DYRK1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sex-specific trisomic Dyrk1a-related skeletal phenotypes during development in a Down syndrome model.PMID 39136051Read ↗

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