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Article

Current Analysis of Skeletal Phenotypes in Down Syndrome.

Current osteoporosis reports - 1 Jun 2021

Thomas Jared R, Roper Randall J

Abstract excerpt

PURPOSE: Down syndrome (DS) is caused by trisomy 21 (Ts21) and results in skeletal deficits including shortened stature, low bone mineral density, and a predisposition to early onset osteoporosis. Ts21 causes significant alterations in skeletal development, morphology of the appendicular skeleton, bone homeostasis, age-related bone loss, and bone strength. However, the genetic or cellular origins of DS skeletal...

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Identifiers

PMID: 33830429
DOI: 10.1007/s11914-021-00674-y
PMCID: PMC8316313

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