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Article

Effects of clinically relevant MPL mutations in the transmembrane domain revealed at the atomic level through computational modeling.

PloS one - 1 Jan 2011

Lee Tai-Sung, Kantarjian Hagop, Ma Wanlong, Yeh Chen-Hsiung, Giles Francis, Albitar Maher

Abstract excerpt

BACKGROUND: Mutations in the thrombopoietin receptor (MPL) may activate relevant pathways and lead to chronic myeloproliferative neoplasms (MPNs). The mechanisms of MPL activation remain elusive because of a lack of experimental structures. Modern computational biology techniques were utilized to explore the mechanisms of MPL protein activation due to various mutations. RESULTS: Transmembrane (TM) domain...

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Source

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Identifiers

PMID: 21858098
DOI: 10.1371/journal.pone.0023396
PMCID: PMC3157383

Genes

MPL
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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