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Article

Differential effects of CSF-1R D802V and KIT D816V homologous mutations on receptor tertiary structure and allosteric communication.

PloS one - 1 Jan 2014

Da Silva Figueiredo Celestino Gomes Priscila, Panel Nicolas, Laine Elodie, Pascutti Pedro Geraldo, Solary Eric, Tchertanov Luba

Abstract excerpt

The colony stimulating factor-1 receptor (CSF-1R) and the stem cell factor receptor KIT, type III receptor tyrosine kinases (RTKs), are important mediators of signal transduction. The normal functions of these receptors can be compromised by gain-of-function mutations associated with different physiopatological impacts. Whereas KIT D816V/H mutation is a well-characterized oncogenic event and principal cause of...

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Source

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Identifiers

PMID: 24828813
DOI: 10.1371/journal.pone.0097519
PMCID: PMC4020833

Genes

KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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