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Deletion or Targeted Blockade of FcγRIIb (CD32b) Impairs α-Syn Propagation <i>In-Vivo</i>

2025-11-18

Abstract excerpt

Parkinson’s disease (PD), the most common neurodegenerative movement disorder, is characterised by pervasive deposition of alpha-synuclein (α-Syn) aggregates and the death of dopaminergic neurons. Fc gamma receptor IIb (FcγRIIb or CD32b), the sole inhibitory FcγR in humans (h) and mice (m), serves as a molecular conduit for intercellular α-Syn transmission in-vitro . Here, we demonstrate that FcγRIIb facilitates...

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Identifiers and source

Literature Corpus work
5075c68c-3131-5faf-ab8e-decd680a558d
DOI
10.1101/2025.11.18.687143
Open publication

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Deletion or Targeted Blockade of FcγRIIb (CD32b) Impairs α-Syn Propagation <i>In-Vivo</i>DOI 10.1101/2025.11.18.687143
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