Article

Early Amyloid-β Deposits and Astrogliosis Are Modulated by Housing Conditions in 5xFAD Mice

2025-05-28

Abstract excerpt

<title>Abstract</title> <p>Epigenetic mechanisms in Alzheimer’s disease (AD) play a determining role in disease progression. To provide further insight on this matter, we evaluated whether early exposure of 5xFAD mice, a transgenic mouse model of AD, to either a standard, isolated or complex environment have a significant effect on the development of pathological hallmarks. Accordingly, we manipulated the animal...

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Literature Corpus work: 505626cc-a7b6-59b5-afa2-0a559d69f72e
DOI: 10.21203/rs.3.rs-6704640/v1

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