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Article

Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer's disease.

Molecular psychiatry - 1 Oct 2025

Lei Yun, Nougaisse Jayvon, Malek Maryam, Mishu Miskatul M, Bai Yu, Denney Kirstyn, Du Quansheng, Stranahan Alexis M, Garza Jacob C, Lu Xin-Yun

Abstract excerpt

Aging and genetic predisposition are the primary risk factors for Alzheimer's disease (AD), while chronic stress represents a modifiable risk factor that can accelerate aging and drive AD progression. However, the complex interplay between aging, chronic stress and genetic underpinnings in AD pathogenesis remains poorly understood. Notably, cognitive phenotyping in AD mouse models has yielded inconsistent...

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Amyloid beta-Protein Precursor
Cognition
Cognition Disorders
Cognitive Dysfunction
Plaque, Amyloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Social Isolation

Stress, Psychological

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Open in PubMed Open full text

Identifiers

PMID: 40467855
DOI: 10.1038/s41380-025-03067-0
PMCID: PMC12436184

Genes

APP
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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