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Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease

1 Jan 2010

Abstract excerpt

The etiology of the sporadic form of Alzheimer's disease (AD) remains largely unknown. Recent evidence has suggested that gene-environment interactions (GxE) may play a crucial role in its development and progression. Whereas various susceptibility loci have been identified, like the apolipoprotein E4 allele, these cannot fully explain the increasing prevalence of AD observed with aging. In addition to such...

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PMID: 20953364
DOI: 10.4061/2010/859101

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