Article
An overview of the serpin superfamily.
Genome biology - 1 Jan 2006
Law Ruby H P, Zhang Qingwei, McGowan Sheena, Buckle Ashley M, Silverman Gary A, Wong Wilson, Rosado Carlos J, Langendorf Chris G, Pike Rob N, Bird Philip I, Whisstock James C
Abstract excerpt
Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.
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