Article
Potential Role for YB-1 in Castration-Resistant Prostate Cancer and Resistance to Enzalutamide Through the Androgen Receptor V7.
Journal of the National Cancer Institute - 1 Jul 2016
Shiota Masaki, Fujimoto Naohiro, Imada Kenjiro, Yokomizo Akira, Itsumi Momoe, Takeuchi Ario, Kuruma Hidetoshi, Inokuchi Junichi, Tatsugami Katsunori, Uchiumi Takeshi, Oda Yoshinao, Naito Seiji
Abstract excerpt
BACKGROUND: Although androgen deprivation therapy for advanced prostate cancer initially exerts excellent anticancer effects, most prostate cancer treated with androgen deprivation therapy eventually recurs as castration-resistant prostate cancer (CRPC). Although aberrant kinase activation has been proposed as a mechanism of castration resistance, comprehensive kinase profiles in CRPC remain unknown. Therefore,...
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