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Article

Correlate tumor mutation burden with immune signatures in human cancers

11 Jan 2019

Abstract excerpt

BACKGROUND: Tumor mutation burden (TMB) has been associated with cancer immunotherapeutic response and cancer prognosis. Although many explorations have revealed that high TMB may yield many neoantigens to incite antitumor immune response, a systematic exploration of the correlation between TMB and immune signatures in different cancer types is lacking. RESULTS: We classified cancer into the lower-TMB subtype and...

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PMID: 30634925
DOI: 10.1186/s12865-018-0285-5

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