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Article

p63 supports aerobic respiration through hexokinase II.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015

Viticchiè Guiditta, Agostini Massimiliano, Lena Anna Maria, Mancini Mara, Zhou Huiqing, Zolla Lello, Dinsdale David, Saintigny Gaelle, Melino Gerry, Candi Eleonora

Abstract excerpt

Short p63 isoform, ΔNp63, is crucial for epidermis formation, and it plays a pivotal role in controlling the turnover of basal keratinocytes by regulating the expression of a subset of genes involved in cell cycle and cell adhesion programs. The glycolytic enzyme hexokinase 2 (HK2) represents the first step of glucose utilization in cells. The family of HKs has four isoforms that differ mainly in their tissue and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26324887
DOI: 10.1073/pnas.1508871112
PMCID: PMC4577137

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