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Accounting for genetic effect heterogeneity in fine-mapping and improving power to detect gene-environment interactions with SharePro

2023-07-30

Abstract excerpt

<h4>Background</h4> Characterizing genetic effect heterogeneity across subpopulations with different environmental exposures is useful for identifying exposure-specific pathways, understanding biological mechanisms underlying disease heterogeneity and further pinpointing modifiable risk factors for disease prevention and management. Classical gene-by-environment interaction (GxE) analysis can be used to character...

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Literature Corpus work: 4ff6b892-c478-56b5-bd3d-deb9e755c7c6
DOI: 10.1101/2023.07.27.550862

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