Article

ASD mutations in the ciliary gene <i>CEP41</i> impact development of projection neurons and interneurons in a human cortical organoid model

2025-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Primary cilia control cell-cell signalling and their dysfunction has been implicated in Autism Spectrum Disorders (ASD) but their roles in the ASD aetiology remain largely unexplored. Here, we analysed the impact of ASD mutations in CEP41 using human corticogenesis. CEP41 encodes a centrosomal protein located at the basal body and the ciliary axoneme and is mutated in ASD individuals and in Jo...

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Literature Corpus work: 7f555a15-deb0-57c8-b056-5a08eee66acb
DOI: 10.1101/2025.07.09.663904

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