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Basal UPR activity in <i>Aspergillus fumigatus</i> regulates adaptation to nutrient stress and is critical for the establishment of corneal infection

2023-05-23

Abstract excerpt

<h4>ABSTRACT</h4> The Aspergillus fumigatus unfolded protein response (UPR) is a two-component relay consisting of the ER-bound IreA protein, which splices and activates the mRNA of the transcription factor HacA. Spliced hacA accumulates under conditions of acute ER stress in vitro , and UPR null mutants are hypovirulent in a murine model of invasive pulmonary infection. In this report, we demonstrate that a...

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Literature Corpus work
24c8f644-6e76-57e2-8c16-86e11081f7c2
DOI
10.1101/2023.05.22.541860
Open publication

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