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Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus <i>Aspergillus fumigatus</i>

2024-04-07

Abstract excerpt

Aspergillus fumigatus is the primary etiological agent of aspergillosis. Here, we show that the host defense peptide mimetic, brilacidin (BRI) can potentiate ibrexafungerp (IBX) against clinical isolates of A. fumigatus . CAS-resistant strains with mutations in fks1 that encodes the 1,3-β-D-glucan synthase are not IBX-resistant and BRI+IBX can inhibit their growth. The combination of BRI+IBX plays a fungicidal r...

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Identifiers and source

Literature Corpus work
7ade7b17-55a7-5784-9656-d54e360e0d45
DOI
10.1101/2024.04.05.588305
Open publication

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Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus <i>Aspergillus fumigatus</i>DOI 10.1101/2024.04.05.588305
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