Article

VirTrack: A Framework for Inferring Viral Influence on Disease-Associated Transcriptomes — Clinical Type-Specific Epstein–Barr Virus Pathogenesis in Multiple Sclerosis

2025-10-06

Abstract excerpt

<h4>Background</h4> Epstein–Barr virus (EBV) is strongly implicated in Multiple Sclerosis (MS), but how its influence varies across MS clinical types remains unclear. <h4>Methods</h4> We developed VirTrack , a computational framework that integrates experimentally validated EBV–host protein–protein interactions (PPIs) with clinical type–specific peripheral blood transcriptomes from Clinically Isolated Syndrome...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5f17690-897e-5ac3-8727-74daa9ee21a9
DOI: 10.1101/2025.10.05.680499

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VirTrack: A Framework for Inferring Viral Influence on Disease-Associated Transcriptomes — Clinical Type-Specific Epstein–Barr Virus Pathogenesis in Multiple SclerosisDOI 10.1101/2025.10.05.680499Read

Exploring the role of EBV in multiple sclerosis pathogenesis through EBV interactomeSemantic proximity Read

Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus associationSemantic proximity Read

A disease-specific convergence of host and Epstein–Barr virus genetics in multiple sclerosisSemantic proximity Read

Comparing Single-Cell Transcriptomes of Blood and Cerebrospinal Fluid Leukocytes in Multiple SclerosisSemantic proximity Read

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis.Semantic proximity Read

An integrated single-cell transcriptomic pipeline identifies ZNF740/BRD3 and Cathepsin S as novel therapeutic targets in chronic active rim smoldering multiple sclerosisSemantic proximity Read

Enhanced EBNA2-dependent activity in EBV-transformed B cells from patients with multiple sclerosisSemantic proximity Read

Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosisSemantic proximity Read

Identification of multiple sclerosis-related genes regulated by EBV-encoded microRNAs in B cellsSemantic proximity Read

Immune Cell Heterogeneity in Multiple Sclerosis Reveals Myeloid-Specific Dysfunction and Distinct Regulatory Programs Across CD14+, CD4+, and CD8+ Immune CellsSemantic proximity Read

Unveiling the Molecular Landscape: Network Analysis of Genes, Proteins, and Transcription Factors in Primary Progressive and Secondary Progressive Multiple Sclerosis for Unraveling Disease Progression and Prognostic FactorsSemantic proximity Read

Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approachesSemantic proximity Read