Article

Management of Asynchronous Multifocal Adult Glioblastoma with Loss of BRAFV600E-Mutant Clonality: A Case Report

2024-11-18

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) classification involves a combination of histological and molecular signatures, including IDH1/2 mutation, TERT promoter mutation, and EGFR amplification. Non-canonical mutations such as BRAF<sup>V600E</sup>, found in 1–2% of GBMs, activate the MEK-ERK signaling pathway. This mutation can be targeted by small molecule inhibitors, offering therapeutic potential for GBM...

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Literature Corpus work: 4f7009d0-2178-5c64-ace9-8ecf049c6ce6
DOI: 10.21203/rs.3.rs-5200565/v1

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