Article
Personalized medicine for glioblastoma: current challenges and future opportunities.
Current molecular medicine - 1 Mar 2013
Zhu J-J, Wong E T
Abstract excerpt
The failure to control glioblastoma progression is a major challenge for neuro-oncologists. Emerging data indicate that genetic and epigenetic heterogeneities within tumor cells play a dominant role in the development of resistant disease. These heterogeneities develop because driver mutations enable the proliferation of certain clones of transformed cells within the tumor microenvironment while pre-existing...
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