Article

Enhanced PIEZO1 Function Contributes to the Pathogenesis of Sickle Cell Disease

2025-03-19

Abstract excerpt

Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the β-globin gene, is characterized by sickle erythrocytes that are prone to hemolysis, causing anemia and vaso-occlusion crises. In sickle erythrocytes, hemoglobin aggregation is followed by altered cation permeability and subsequent dehydration. Interventions to restore cation permeability can decrease hemolysis and ameliorate the sym...

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Literature Corpus work: ac5d3006-dc73-5e68-a18c-15d3bd84a164
DOI: 10.1101/2025.03.19.643952

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