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PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells

1 Jan 2024

Abstract excerpt

INTRODUCTION: Leukemogenesis is a complex process that interconnects tumoral cells with their microenvironment, but the effect of mechanosensing in acute myeloid leukemia (AML) blasts is poorly known. PIEZO1 perceives and transmits the constraints of the environment to human cells by acting as a non-selective calcium channel, but very little is known about its role in leukemogenesis. RESULTS: For the first time,...

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PMID: 38334477
DOI: 10.1002/cam4.6984

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