Article

More Insights into the Relation between DNA Ionization Potentials, Single Base Substitutions and Pathogenic Mutations

2018-10-04

Abstract excerpt

It is nowadays clear that the single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, despite recent progress, the understanding of these “non-local” effects is still far from being achieved. In order to advance this problem, we analyzed the relationship between the base mutability in gene...

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Literature Corpus work: 4f38022a-ccff-5895-b121-746b86132877
DOI: 10.1101/435354

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