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DNA spontaneous mutation and its role in the evolution of GC-content: assessing the impact of the genetic sequence.

Physical chemistry chemical physics : PCCP - 28 Mar 2015

Cerón-Carrasco José P, Jacquemin Denis

Abstract excerpt

The structure of DNA is not constantly at its equilibrium point but evolves with time. It is generally accepted that evolution induces a decrease of the guanine-cytosine (GC) content and a concomitant increase of the adenine-thymine (AT) ratio through a biased GC → AT mutation process. Unfortunately, the mechanism behind this natural alteration of the stored genetic information is not fully understood. Here, we...

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PMID: 25715061
DOI: 10.1039/c4cp05806b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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