Back to search

Article

Unraveling the spatial landscape of Dystrophinopathies: a transcriptomic approach to Becker and Duchenne muscular dystrophies

2025-05-31

Abstract excerpt

Dystrophinopathies are caused by pathogenic variants in the DMD gene resulting in partial (Becker) or complete loss (Duchenne) of dystrophin. Becker (BMD) and Duchenne muscular dystrophy (DMD), are characterized by progressive muscle wasting, fatty replacement, fibrosis, and loss of function. To study histopathological changes, we used spatial transcriptomics to profile skeletal muscle biopsies of BMD, DMD patient...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0473f7ab-f7c2-5955-9902-2f09bd1b5f21
DOI
10.1101/2025.05.30.25328395
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Unraveling the spatial landscape of Dystrophinopathies: a transcriptomic approach to Becker and Duchenne muscular dystrophiesDOI 10.1101/2025.05.30.25328395
Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse modelsSemantic proximity
A cellular and molecular spatial atlas of dystrophic muscleSemantic proximity
Decoding Duchenne muscular dystrophy transcriptome to single nuclei level reveals clinical-genetic correlationsSemantic proximity
Single cell RNA sequencing of human FAPs reveals different functional stages in Duchenne muscular dystrophySemantic proximity
Single nuclei/cell transcriptomics reveal DMD driven cell dynamics and mechanisms of fibroblast inflammatory tissue priming in human dystrophic muscleSemantic proximity
Transcriptomic analysis of paired healthy human skeletal muscles to identify modulators of disease severity in DMDSemantic proximity
Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescueSemantic proximity
Late-Stage Skeletal Muscle Transcriptome in Duchenne muscular dystrophy shows a BMP4-Induced Molecular SignatureSemantic proximity
Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescueSemantic proximity
Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse modelsSemantic proximity
Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscleSemantic proximity
Compartment-specific remodeling of skeletal muscle in Duchenne muscular dystrophySemantic proximity
Select a neighboring publication to make it the new centre.