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Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, <i>MX2</i> , in melanoma promotion

2019-05-02

Abstract excerpt

Genome-wide association studies (GWAS) have identified ∼20 melanoma susceptibility loci. To identify susceptibility genes and variants simultaneously from multiple GWAS loci, we integrated massively-parallel reporter assays (MPRA) with cell type-specific epigenomic data as well as melanocyte-specific expression quantitative trait loci (eQTL) profiling. Starting from 16 melanoma loci, we selected 832 variants overl...

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Literature Corpus work
82f75a40-57bc-5db8-9d1d-219c894ad58a
DOI
10.1101/625400
Open publication

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Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, <i>MX2</i> , in melanoma promotionDOI 10.1101/625400
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