Article
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology - 1 Jan 2018
Horiguchi Hiroyuki, Loftus Tyler J, Hawkins Russell B, Raymond Steven L, Stortz Julie A, Hollen McKenzie K, Weiss Brett P, Miller Elizabeth S, Bihorac Azra, Larson Shawn D, Mohr Alicia M, Brakenridge Scott C, Tsujimoto Hironori, Ueno Hideki, Moore Frederick A, Moldawer Lyle L, Efron Philip A
Abstract excerpt
Clinical and technological advances promoting early hemorrhage control and physiologic resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly decreased in-hospital mortality for many critically ill patient populations. However, a substantial proportion of severe trauma and sepsis survivors will develop protracted organ dysfunction termed chronic critical illness (CCI), defined...
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