Mycobacterium tuberculosis growth arrest on propionate at acidic pH is suppressed by mutations in phoPR and pyrazinamide treatment.

Abstract excerpt

Mycobacterium tuberculosis (Mtb) arrests its growth at acidic pH when grown on specific single carbon sources, including propionate. However, Mtb grows well on propionate at pH 7.0, supporting that propionate can support growth as a sole carbon source. To understand the basis of the propionate-driven growth arrest at acidic pH, we performed a forward genetic selection for mutants that enable growth on propionate...

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• Antitubercular Agents
• Bacterial Proteins
• Citrates
• Gene Expression Regulation, Bacterial
• Hydrogen-Ion Concentration