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Article

Endothelial lipase promotes acute myeloid leukemia progression through metabolic reprogramming.

Neoplasma - 1 Jul 2022

Shang Si-Qi, Yang Ying, Yang Xue-Jiao, Shi Xiao-Dong, Chen Yun-Shuo, Wang Yue-Ying

Abstract excerpt

Metabolic reprogramming occurs in the clonal evolution of acute myeloid leukemia (AML), which contributes to cell survival under metabolic stress and the development of drug resistance. Leukemic cells exhibit various metabolic profiles, which involve multiple metabolic pathways due to the heterogeneity of AML. However, studies on metabolic targets for AML treatment are mostly focused on glycolysis at present. In...

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PMID: 35263993
DOI: 10.4149/neo_2022_211004N1408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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