Article

Screening for novel RyR2 inhibitors by ER Ca <sup>2+</sup> monitoring

2023-08-22

Abstract excerpt

Type 2 ryanodine receptor (RyR2) is a Ca 2+ release channel on the endoplasmic/sarcoplasmic reticulum (ER/SR) that plays a central role in the excitation-contraction coupling in the heart. Hyperactivity of RyR2 has been linked to ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) and heart failure, where spontaneous Ca 2+ release via hyperactivated RyR2 depolari...

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Literature Corpus work: 62594b7c-8dda-5edf-baa4-4259bfccf4ba
DOI: 10.1101/2023.08.21.553510

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