Article

Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

2020-06-12

Abstract excerpt

The transcription factor (TF) p53 is the best-known tumor suppressor, but its ancient sibling p63 (ΔNp63) is a master regulator of epidermis development and a key oncogenic driver in squamous cell carcinomas (SCC). Despite multiple gene expression studies becoming available in recent years, the limited overlap of reported p63-dependent genes has made it difficult to decipher the p63 gene regulatory network (GRN)....

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Literature Corpus work: 4ed79817-b438-5a55-ac2a-0b0525df6f38
DOI: 10.1101/2020.06.11.145540

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