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Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

2 Dec 2020

Abstract excerpt

The transcription factor p53 is the best-known tumor suppressor, but its sibling p63 is a master regulator of epidermis development and a key oncogenic driver in squamous cell carcinomas (SCC). Despite multiple gene expression studies becoming available, the limited overlap of reported p63-dependent genes has made it difficult to decipher the p63 gene regulatory network. Particularly, analyses of p63 response...

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PMID: 33263276
DOI: 10.7554/elife.63266

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