Article

Mutant p63 affects epidermal cell identity through rewiring the enhancer landscape

2018-08-09

Abstract excerpt

Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and differentiation. In humans mutations in p63 cause several developmental disorders with defects of ectoderm-derived structures including the epidermis. The underlying molecular mechanisms of these mutations however remain unclear. Here we characterized the transcriptome and epigenome from EEC syndrome patients carrying mutations...

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Literature Corpus work: 0654a6f2-ec79-5f2d-bf6a-7c747fca4d71
DOI: 10.1101/387902

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