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Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection

8 Dec 2020

Abstract excerpt

The entry of SARS-CoV-2 into target cells requires the activation of its surface spike protein, S, by host proteases. The host serine protease TMPRSS2 and cysteine proteases Cathepsin B/L can activate S, making two independent entry pathways accessible to SARS-CoV-2. Blocking the proteases prevents SARS-CoV-2 entry in vitro. This blockade may be achieved in vivo through 'repurposing' drugs, a potential treatment...

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PMID: 33290397
DOI: 10.1371/journal.pcbi.1008461

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