Article

T-regulatory cell protection of progenitor cells from CD4 <sup>+</sup> T-cell-mediated cytotoxicity is essential for endogenous mouse digit-tip regeneration

2025-11-19

Abstract excerpt

Regeneration of amputated digit tips in humans and mice relies on osteoclast-dependent bone erosion coupled with osteoblast-mediated bone replacement. Currently, little is known of the impact of lymphoid immune cells, i.e., T cells, B cells, and NK cells, on digit-tip regeneration. Using lymphoid-deficient mutant mice, we revealed lymphoid immunity as a net negative regulator of regeneration. CD8 + cells are thou...

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Literature Corpus work: 4ecd2814-7193-58ac-bf5c-5ab160cb30fd
DOI: 10.1101/2025.11.19.689270

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T-regulatory cell protection of progenitor cells from CD4 <sup>+</sup> T-cell-mediated cytotoxicity is essential for endogenous mouse digit-tip regenerationDOI 10.1101/2025.11.19.689270Read

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