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Article

Treg cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2018

Panduro Marisella, Benoist Christophe, Mathis Diane

Abstract excerpt

Skeletal muscle regeneration is a highly orchestrated process that depends on multiple immune-system cell types, notably macrophages (MFs) and Foxp3+CD4+ regulatory T (Treg) cells. This study addressed how Treg cells rein in MFs during regeneration of murine muscle after acute injury with cardiotoxin. We first delineated and characterized two subsets of MFs according to their expression of major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29476012
DOI: 10.1073/pnas.1800618115
PMCID: PMC5856564

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