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The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2

2024-08-09

Abstract excerpt

SARS-CoV-2 continues to pose a threat to public health. Current therapeutics remain limited to direct acting antivirals that lack distinct mechanisms of action and are already showing signs of viral resistance. The virus encodes an ADP-ribosylhydrolase macrodomain (Mac1) that plays an important role in the coronaviral lifecycle by suppressing host innate immune responses. Genetic inactivation of Mac1 abrogates vir...

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Identifiers and source

Literature Corpus work
4eb0571a-fd6f-5633-a975-2cd20acc2430
DOI
10.1101/2024.08.08.606661
Open publication

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The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2DOI 10.1101/2024.08.08.606661
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