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Interactomics of SARS-CoV-2 Macrodomain 1 Reveals Putative Clients of ADP-Ribosyl Hydrolase Activity.

Viruses - 22 May 2026

Cameron Crissey D, Heilmann Grace, Roman Brynn K, Plate Lars

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has greatly impacted public health due to high rates of transmissibility and mutation during the COVID-19 pandemic. Macrodomain 1 (Mac1) of non-structural protein 3 remained well conserved across variants and is critical to suppression of host immune response to infection, making Mac1 a promising target for therapeutic development. Mac1 binds and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42357598
DOI: 10.3390/v18060587
PMCID: PMC13307864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Interactomics of SARS-CoV-2 Macrodomain 1 Reveals Putative Clients of ADP-Ribosyl Hydrolase Activity.PMID 42357598Read ↗

Interactomics of SARS-CoV-2 Macrodomain 1 Reveals Putative Clients of ADP-ribosyl Hydrolase ActivitySemantic proximity Read ↗

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The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2Semantic proximity Read ↗

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